Postdoctoral position to study Protein-Protein Interactions and
their role in Mechanisms of Signal Transduction using protein solution
NMR /x-ray crystallography
Case Medical School, Cleveland, Ohio,
USA
How are signaling
events transmitted from one protein to another? To answer this
question we are looking to add a postdoctoral co-workers to our
interdisciplinary team. Our interest is to understand protein-protein
interactions, protein structure and dynamics in the context of cell
signaling mechanisms. {e.g. see our recent papers J.Biol.Chem.,282, 37215-37224 (2007),
Structure 16, 246-258 (2008) and J.Mol.Biol. 377, 1474-87 (2008)}.
The systems include several small GTPases and their interacting
proteins, principally the cytoplasmic domains of plexins and of other
receptors.
Research in protein biophysics/structural
biology. We principally use solution NMR for protein structure
determination, surface mapping and characterization of conformational
change. The project may involve amide hydrogen exchange, NMR relaxation
and molecular dynamics simulation as additional tools. NMR facilities at the Cleveland Center for
Structural Biology consist of two
600 MHz, an 800 MHz and an 900 MHz Bruker spectrometers all with
cryoprobes, making the Center one of
the premier NMR facilities in the US. Apart from NMR, we employ
other biophysical techniques including circular dichroism and
fluorescence spectroscopy as well as isothermal titration calorimetry
(ITC). Recently have started x-ray
crystallography as a second major component to the laboratory (a
Rigaku MicroMax-007 HF instrument with a 94x94mm CCD detector has
recently been installed for crystal screening) and are also moving into
cell biology.
We are looking for
talented and motivated coworkers, who aim to become independent
researchers/project leaders. Prior experience with protein NMR or x-ray
crystallography is essential.. The Buck laboratory provides a
stimulating but friendly working environment – we are still relatively
small & young, which has advantages. The Medical School of Case
Western Reserve University is highly rated overall in the US (~ 13th in
terms of NIH funding) and Cleveland is a pleasant but affordable place
to live with excellent educational, medical and cultural institutions.
Starting date, project details and salary are negotiable. Please check
out our lab. page for further
details at http://mbalster.case.edu/;
if interested, please send your resume, overview of your scientific
interests and career goals as well as contact details of three referees
able to provide references by e-mail to Matthias.Buck@case.edu
