Reference Hyph-05: Post-Doc, Biomolecular NMR in application to
metabolomics (2-3 years)
Spinnovation, Nijmegen, The Netherlands
Spinnovation Analytical
BV is a private Contract Research Organization located in Nijmegen, The
Netherlands. The company is specialized in offering analytical service
and contract research to Industry carrying out intense Research &
Development effort in the field of Pharmaceuticals, Chemicals/Polymers
or Food Products. Its expertise and capacity are focused on NMR-based
spectroscopic techniques and applications. Since its establishment in
2004, Spinnovation has established itself as a leading company on the
worldwide market of NMR-based analytical services.
Spinnovation has currently an opened post-doctoral position in the
field of biomolecular NMR applied to metabolomics.
Description. The project is
based on a joint research initiative from several industrial
(Pharmaceutical companies, analytical system supplier and service
supplier) and academic parties. The project deals with the development
and use of NMR-based analytical methods, in combination with LC/MS and
LC/SPE, in the study of biological fluids for metabonomic applications.
Spectrometric, spectroscopic, and chromatographic data will be used to
establish unambiguous identification / characterization of endogenous
metabolites develop profiling methods, support enrichment of existing
database. For e.g., specific measurement of NMR parameters such as
relaxation times will be carried out and issues related to
protein/metabolite interactions will be addressed.
Spinnovation analytical platform
combines state-of-the-art LC-SPE-NMR-MS methods, dedicated analytical
systems and applications developed to address issues in the field of
metabolomic (automation, throughput, sensitivity, dedicated
database...). Spinnovation has a staff of highly skilled and
experienced employees (researchers and engineers. NMR capacity is
further supported by the access to an NMR facility with spectrometers
operating at 500MHz, 600MHz and 800MHz and fitted with cryo-cooled
probes.
Candidate profile. The
candidate (m/f) will have a Ph.D. in biophysical chemistry with a
speciality in bio-molecular NMR. He/she will have a significant
background and expertise in NMR theory and operation (pulse
programming, data acquisition, processing and troubleshooting),
expertise that he/she would for instance have applied to solution NMR
protein structure investigation. Additional expertise in chemometrics,
metabolomics/nomics, other analytical methods such as MS, LC-MS will be
valued.
The candidate should be interested in applied science and technological
aspects, efficient in teamwork, have broad scientific interest,
recognized organizational skills, with validated project management
experience, be opened with good communication ability (oral / writing),
fluent in English.
Further information and application.
The position will be opened at Spinnovation, Nijmegen (The
Netherlands). Salary will be discussed according to experience.
Application shall be sent in English, including CV, accompanying letter
and names of two reference persons that can be contacted, by email to
the address: recruitment@spinnovation.eu
, mentioning the position reference ref.
Hyph-05 in the subject.
