NMR Spectroscopist /
Scientific Associate II, Structural Chemistry
Req.
No.
59935BR
NIBR - Novarits
Emeryville, California
About Novartis Institute of Biomedical Research:
At Novartis Institutes for BioMedical Research
(“NIBR”), the global research organization of Novartis, we are
committed to discovering innovative medicines to cure disease and
improve human health. By hiring the best academic, biotech, and
pharmaceutical trained scientists, we have fostered and atmosphere for
drug discovery where innovation is rewarded. It is ultimately the
talent of the individual that determines our success, while our
state-of-the-art technologies and resources enable these ideas to be
realized.
NIBR has sites in Cambridge, Massachusetts;
Emeryville, CA; Basel, Switzerland; Horsham, UK; and Shanghai, China.
Our Emeryville location focuses on early drug discovery efforts for the
Oncology Disease Area and offers a variety of positions in Biology,
Chemistry, and functions such as Technology, Patents, Research Sciences
and other areas that support our scientific resources.
About Structural Chemistry:
The NIBR Emeryville Structural Chemistry group is
responsible for actively pursuing the structures of macromolecular drug
targets either as apo-proteins or in complex with lead compounds to
help guide structure-based drug design, and actively participates in
the drug discovery process. The group also provides biophysics and
solutions studies support for drug discovery projects.
About the position:
- The successful candidate will be an integral member of drug
discovery teams and will assist in the execution of receptor-ligand
interaction studies by biophysical methods.
- He or she will work closely with the scientists in protein
biochemistry, computational chemistry, medicinal chemistry, and protein
crystallography in providing support for structure-based drug design.
- He or she will provide hands-on NMR sample preparation, as
well as NMR data acquisition and processing, focused on assessing
ligand-binding and analyzing the solution structures of proteins and
protein:ligand complexes.
- The candidate will help to establish an in-house NMR lab
consisting of a 600 MHz spectrometer with associated computing and
robotics.
The ideal candidate will have:
- A B.A. or M.S. or equivalent in Biochemistry, Chemistry, or
Molecular Biology
- At least 3 years (M.S.) or 5 years (B.A.) of work
experience with demonstrated success in biophysical techniques
- Experience in preparation of biomolecular samples for NMR
data collection, as well as data collection as applied to ligand-based
studies
- A background in protein biochemistry and biophysical
characterization of protein:ligand interaction, particularly ITC, DSC,
and surface plasmon resonance
- Experience in protein biochemistry and fragment-based
screening is desirable
- Strong communication skills
- The ability to work in large, multidisciplinary drug
discovery teams
To apply for this position, please visit
www.novartis.com,
click
on the Careers link, pull the menu down to Job Search US, select
the link to “Novartis Institutes for BioMedical Research (NIBR) in
Emeryville, CA, and click on the link for the job (
59935BR).
