Protein NMR Post-doctoral Position at Pfizer-Cambridge

    The protein NMR group at Pfizer in Cambridge, MA has an opening for a highly motivated post doctoral fellow to continue a successful collaborative study with the Pfizer Vaccines group.  Protein NMR is part of the Biotherapeutic Engineering and Production (BEP) group and focuses on the structural characterization of important biologic molecules.  The current post doctoral project involves structural determination of proteins expressed on the surface of Neisseria meningitidis, in specific the subfamily A of  LP 2086 family.  LP 2086 is also known as Factor H binding protein, and we are interested in learning how subfamily A proteins interact with Factor H as well as bactericidal monoclonal antibodies.   

    The ideal candidate should hold a Ph.D. degree in Chemistry, Biophysics or related fields and have demonstrated experience in the area of biomolecular NMR and protein production.  This includes protein expression/purification, data acquisition and analysis of multi-dimensional NMR data, and interpretation of NMR data for protein structure determination.  Knowledge of pulse sequence implementation and design is also desirable but not required.  The candidate should also possess excellent written and verbal communication skills.

    Our laboratory holds  a Bruker 600 and 700 MHz spectrometers with cryoprobes and autosamplers, and a Tecan platform for automated sample preparation.  As part of BEP, we work closely and interact with other groups, including  X-ray crystallography, computational chemistry and biophysics. 

     The position is available immediately, and all qualified candidates are encouraged to apply.  Please send your CV with references to: