Two
solution NMR postdoctoral positions at
University of California San Diego
University
of California San Diego, La Jolla, CA, USA
Two post-doctoral positions are available in the
group of Dr. Lalit Deshmukh at the
Department of Chemistry and Biochemistry at
University of California San Diego (UCSD). Both
positions will be available for 2 years with the
possibility of extension. The lab is interested in
understanding the interplay between retroviral
group-specific antigen (Gag) polyproteins and host
cellular factors and primarily utilizes solution NMR
spectroscopy to answer challenging questions. We
seek two new members to join the group to expand our
current work on retroviral Gag polyproteins and
their interactions with endosomal sorting complexes
required for transport (ESCRT) machinery as well as
their association with artificial lipid membranes
such as lipid nanodiscs. We will explore the
role of Gag ubiquitination in Gag-ESCRT interactions
and analyze the impact of myristoylation on
Gag-membrane association.
Recent publications include –
1) Deshmukh, L.,
Tugarinov, V., Appella D. H., and Clore, G. M.
(2018) Targeting a dark excited state of HIV-1
nucleocapsid by anti-retroviral thioesters
revealed by NMR. Angew Chem Int Ed Engl57,
2687-2691.
2) Deshmukh, L., Tugarinov, V.,
Louis, J. M., and Clore, G. M. (2017) Binding
Kinetics and Substrate Selectivity in HIV-1
Protease-Gag Interactions Probed at Atomic
Resolution by Chemical-Exchange NMR. Proc Natl
Acad Sci U S A 114, E9855-E9862.
3) Deshmukh, L., Louis, J. M.,
Ghirlando, R., and Clore, G. M. (2016) Transient
HIV-1 Gag-Protease Interactions Revealed by
Paramagnetic NMR Suggest Origins of Compensatory
Drug Resistance Mutations. Proc Natl Acad Sci U S
A 113, 12456-12461.
The lab is located in the Natural Sciences Building
at UCSD and has dedicated access to state-of-the-art
solution NMR equipment (for more details, please
visit – http://nmr.ucsd.edu/biomolecular.html).
In addition, the Department provides an excellent
cross-disciplinary environment with training
opportunities and modern research facilities to
carry out collaborative research.
Requirements: Interested candidates must have
received (or be expecting) a Ph.D. and/or M.D.
within the past two years in biochemistry /
biophysics / molecular or structural biology. Strong
background in solution NMR, computational methods,
protein expression and purification, lipid
chemistry, and structural biology is highly
desirable. Candidates should be highly
motivated, open to new approaches and techniques,
and be able to tackle demanding challenges.
To apply: Please email (as one single pdf
document) a preferred start date, CV, a brief
summary of research interests and accomplishments,
career goals, and names and contact information of
at least three references to: Dr. Lalit Deshmukh,
Email: ldeshmukh@ucsd.edu.
UC San Diego is an Equal Opportunity/Affirmative
Action Employer with a strong institutional
commitment to excellence through diversity. All
qualified applicants will receive consideration for
employment without regard to gender, race, color,
religion, sex, sexual orientation, national origin,
disability, age or protected veteran status.
Salary: Commensurate with qualification and
based on UCSD Postdoc salary scale.
Lalit Deshmukh, Ph.D.
Assistant Professor
Department of Chemistry and Biochemistry
University of California San Diego
9500 Gilman Drive
La Jolla, CA 92093 http://deshmukhgroup.ucsd.edu/
